Epigenetics, microRNA and Metabolic Syndrome: A Comprehensive Review

Epigenetics refers to the DNA chemistry changes that result in modification of gene transcription and translation independently underlying coding sequence. Epigenetic modifications are reported involve various molecular mechanisms, including classical epigenetic affecting methylation histone small RNA-mediated processes, particularly microRNAs. reversible closely interconnected. They recognised play a critical role as mediators regulation, any alteration these mechanisms has been identified mediate pathophysiological conditions. Moreover, genetic predisposition environmental factors, dietary alterations, lifestyle or metabolic status, interact with human epigenome, highlighting importance factors processes aetiology diseases such MetS. This review will reflect on how both microRNA-regulated associated pathophysiology syndrome. We then focus aspects epigenetic-based strategies used modify MetS outcomes, diet, drugs, epigenome editing tools miRNA-based therapies.